Brigham and Women's Hospital, Harvard Medical School
January 27, 2021
Boston, MA
Job Type
Contact Person/Department
Peng Li, Ph.D.


The Medical Biodynamics Program (MBP) was established in 2011 to promote the applications of novel concepts and methods derived from modern statistical physics, nonlinear dynamics, and biomedical engineering to medicine. In collaboration with a group of PhD and MD scientists with backgrounds in physiology, statistical physics, biomedical engineering, and computational neurosciences, the research in the MBP encompasses a range of neurophysiological systems that are linked to or interact with sleep and circadian regulation (see

Funded by the National Institutes of Health (three RF1 or R03 grants) and the BrightFocus Foundation (a three-year standard award), the on-going projects in the MBP are focused on understanding of non-cognitive physiological changes such as motor control, sleep, and circadian regulation during the progression of Alzheimer’s disease (AD), and developing non-invasive biomarker(s) for the risk of AD using motor activity and genetic data. The postdoc will lead one of the projects, in which the relationship between circadian function, autonomic regulation and the risk of Alzheimer’s dementia will be determined by studying wrist actigraphy and pulse oximetry data of over 1,000 old participants. The postdoc will be able to get involved in other ongoing projects such as ‘Chronic Pain in Shift workers’, ‘Circadian/sleep disruption and incident delirium and postoperative cognitive dysfunction’, ‘Fractal regulation and Alzheimer’s disease in middle-to-old subjects’, and ‘Circadian function and cognitive performance in people living with HIV-infection’. The postdoc will also have the opportunity to (i) learn or participate in the development of new tools for complex physiological data analysis, (ii) obtain sophisticated training in sleep and circadian physiology, and (iii) gain exposure to perioperative outcomes and potential future clinical research.

Qualifications: We are looking for a highly motivated individual with a Ph.D. or M.D., and a background/strong interest in sleep/circadian physiology, cognition, computational neuroscience, and/or neurophysiology. An applicant with experience in programming languages such as, Matlab/Python/R, and/or big data processing will be preferred. A strong applicant will be highly proactive, independent, and an effective communicator. To apply, send your CV (with the contact information of three references) by email to Dr. Peng Li ([email protected]), Dr. Kun Hu ([email protected]), or Dr. Lei Gao ([email protected]).

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