The Medical Biodynamics Program (MBP) was established in 2011 to promote the applications of novel concepts and methods derived from modern statistical physics, nonlinear dynamics, and biomedical engineering to medicine. The research in the MBP covers a range of neurophysiological systems that are linked to or interact with sleep and circadian regulation (see details in https://sleep.med.harvard.edu/research/labs/112/Medical+Biodynamics+Program+MBP). Directly related to this postdoctoral position, two of our on-going projects funded by the National Institutes of Health are focused on the understanding of physiological changes during the progression of Alzheimer’s disease (AD) and the development of non-invasive biomarker(s) for the risk of Alzheimer’s dementia using motor activity and genetic data. The postdoc will lead one of the projects, in which four categories of physiological functions (i.e., physical activity, sleep, circadian rest-active patterns, and fractal motor regulation) will be assessed from motor activity recordings of ~1,400 old participants collected at Rush Alzheimer’s Disease Center, and will be used to construct an integrated biomarker for the risk of Alzheimer’s dementia with deep learning. The genetic data and postmortem AD pathological data of the same participants will be also used to test whether the constructed biomarker modifies or interacts with the genetic effect on the risk for AD, and how specifically the biomarker predict the pathologies of AD in the brain, brainstem and spinal cord. In addition, the postdoc will be actively involved and assist with many other ongoing projects (depending on the applicant’s interests) such as ‘Chronic Pain in Shift workers’ and ‘Circadian disruption and neuroanatomical changes in the development of delirium and postoperative cognitive dysfunction’ (see the MBP website). The postdoc will have the opportunity to (i) learn or participate in the development of new tools for complex physiological data analysis; and (ii) obtain sophisticated training in sleep and circadian physiology.