Ancillary Studies in Clinical Trials (R01) (RFA-HL-14-004)
NHLBI invites research grant applications to conduct time-sensitive ancillary studies related to heart, lung, and blood diseases and sleep disorders in conjunction with ongoing clinical trials and other large clinical studies supported by NIH or non-NIH entities.
NOTE: This RFA requires a compelling and transparent rationale to justify the expedited review under this program.
Secondary Dataset Analyses in Heart, Lung, and Blood Diseases and Sleep Disorders (R21)
The National Heart, Lung, and Blood Institute (NHLBI) invites R21 applications for well-focused secondary analyses of existing human datasets to test innovative hypotheses concerning the epidemiology, pathophysiology, prevention or treatment of diseases/conditions highly relevant to the NHLBI mission. Applicants may use data from a variety of sources, including, but not limited to, investigator-initiated research activities, contracts from public or private sources, administrative data bases, the NHLBI BioLINCC resource (https://biolincc.nhlbi.nih.gov/home/).
Alcohol Abuse, Sleep Disorders and Circadian Rhythms (R21/R01)
The National Institute on Alcohol Abuse and Alcoholism (NIAAA), invites R21 and R01 applications proposing to conduct studies on the functional relationships between alcohol abuse, circadian rhythms and sleep disorders. Collaborative efforts between experts in circadian and/or sleep research and established alcohol investigators to facilitate the development of proposals incorporating both areas of research are encouraged.
These announcements include special programmatic considerations. It is critical that applicants considering the possibility of developing an application carefully read the full text of the announcement and consult with the listed NIAAA staff contact.
Functional Assays to Screen Genomic Hits (R21/R33)(RFA-HL-13-027)
National Heart, Lung, and Blood Institute (NHLBI) invites applications to conduct functional analyses of identified genetic variations related to heart, lung, blood and sleep phenotypes, using amenable in vitro or animal model systems. Exploratory/Developmental Phased Innovation (R21/R33) grant applications should identify and justify the genetic variants that they propose to test for functionality, the phenotype(s) the variants are associated with, and the functional measures that will be used to validate them. This FOA provides support for two years (R21 phase) for research planning activities and feasibility studies, followed by possible transition of up to three years of expanded research support (R33 phase).
NHLBI Clinical Trial Pilot Studies (R34) (PAR-13-002)
NHLBI invites applications proposing pilot studies to obtain data critical for the design of robust clinical trials. This Funding Opportunity Announcement (FOA) should be used to fill gaps in scientific knowledge necessary to develop a competitive full-scale clinical trial. Proposals that primarily aim to organize studies would not be responsive.
Exploratory/Developmental Bioengineering Research Grants (EBRG) [R21] (PA-12-284)
Exploratory/Developmental Bioengineering Research Grants (EBRG) establish the feasibility of technologies, techniques or methods that: 1) explore a unique multidisciplinary approach to a biomedical challenge; 2) are high-risk but have a considerable pay-off; and 3) develop data which can lead to significant future research.
An EBRG application may propose hypothesis-driven, discovery-driven, developmental, or design-directed research and is appropriate for evaluating unproven approaches for which there is minimal or no preliminary data.
Education Research in Sleep Health and Sleep-Circadian Biology (R25)
This initiative invites educational research (R25) grant applications focused on scientific advances in sleep health and circadian and sleep biology. The goal is to stimulate development of innovative, well-validated education tools, platforms and programs that will transfer health information and scientific advances in sleep and circadian biology to research scientists, health care providers, and educators, to specific populations including youth, older adults, women, racial and ethnic minorities, and veterans. Proposals are to address plans for future partnerships with appropriate stakeholder communities that could potentially facilitate dissemination and implementation. Applications from interested educational and outreach researchers partnering with appropriate expertise are encouraged.