The IOM report noted a number of methodological limitations of the population-based studies, particularly studies of MI risk following smoking ban implementation. Although some of these limitations are inherent in population research of uncontrolled policy changes, methodological improvements such as obtaining individual-level data on smoking status, accounting for potential confounders such as other cardiovascular risk factors, assessing biomarkers or environmental sensor levels of SHS exposure, evaluating potential disease process biomarkers, and sensitivity analyses of models and assumptions would allow for better estimation of magnitude of the dose-response relationship. Prospective population-based studies may be needed to address these methodological concerns, but the IOM committee noted that a number of existing cohort studies could be leveraged to better characterize the dose-relationship of SHS exposure and cardiovascular disease and pathophysiology. These cohort studies include, but are not limited to Multi-Ethnic Study of Atherosclerosis (MESA), American Cancer Society's CPS-3, European Prospective Investigation of Cancer (EPIC), Framingham Heart Study, and Jackson Heart Study. Links to NHLBI-sponsored epidemiology studies that could be utilized for this purpose can be found at: http://www.nhlbi.nih.gov/resources/epidemiology.htm, and from the BioLINCC repository (https://biolincc.nhlbi.nih.gov/home/). Therefore, research in response to this FOA may propose a prospective cohort study or utilize existing databases to address the cardiovascular and pulmonary mechanisms affected by secondhand smoke exposure and the dose-response characteristics of these relationships. To view the entire RFA click on the following link: http://grants.nih.gov/grants/guide/pa-files/PA-11-244.html
Obesity and Asthma: Awareness and Management (NINR - R01)
Asthma is a chronic condition involving the respiratory system in which the airways intermittently constrict, become inflamed, and are lined with excessive amounts of mucus, often in response to one or more triggers. Examples of triggers of asthma include upper respiratory infections, allergens (house dust mites, cockroach, pollens, molds, and animal epithelials), exercise, and cold air. Epidemiologic studies suggest there is a dose-effect relationship between weight and asthma. In the adult, co-morbidities of diseases associated with obesity (e.g., dyslippidemia, gastroesophageal reflux disease (GERD), sleep-disordered breathing, and type 2 diabetes) may provoke or worsen asthma. Both asthma and obesity are considered inflammatory conditions. These data suggest that obesity and asthma may share a common etiology. Further understanding of the mechanistic basis for the relationship between obesity and asthma may lead to new therapeutic strategies for treatment in this population. For more information click on the following link: http://grants.nih.gov/grants/guide/pa-files/PA-11-245.html
Instrument Development for Biomedical Applications (R21)
The primary intent of this FOA is to stimulate the development of instrumentation for biomedical research that will support achievement of biomedical breakthroughs. High-risk applications are encouraged.
NCRR solicits innovative proposals focused on the development of new or improved instrumentation. Development of methodologies and software may be included to the extent that they advance instrument development. Projects should propose tools that can be used by a wide range of biomedical or clinical researchers. Projects that are focused on a specific organ or disease will be considered nonresponsive and withdrawn without review; however, a specific organ or disease may be used as a model system to evaluate the new instrumentation. Since the R21 mechanism is designed to support applications with few or no preliminary findings, investigators with substantial preliminary data should submit under a different mechanism.
The proposed research may involve conceptualization, design, fabrication, and/or testing of new instruments or devices, including control software. The overall objective of applications for new instruments should be the development of more powerful and more precise technology with broad applicability to biomedical research. Examples of new tools and techniques that are responsive to this FOA include optical spectroscopy, mass spectrometry, electrophoresis and other separation techniques, microscopy, lasers and optics, X-ray tools, nuclear magnetic resonance spectroscopy, bioreactors, centrifugation, proteomics, genomic sequencing, functional genomics, comparative genomics, microarrays, and human sequence variation (e.g., genotyping). This list is not exhaustive, but investigators with topics outside of these areas are strongly encouraged to contact program staff to ensure that their applications are responsive.
View the entire RFA by clicking the following link: http://grants.nih.gov/grants/guide/rfa-files/RFA-RR-11-005.html
Pediatric Scientist Development Program (PSDP) [K12]
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, invites applications for pediatric scientist research career development (K12) programs. The program will be responsible for identifying pediatricians who have completed their clinical training and have promising research potential, and for matching them with established mentors with a strong record of research productivity. The program will develop guidelines for mentoring and career development in order to promote the successful transition of the candidates into independent research careers in academic settings. The proposed PSDP may complement other, ongoing research training and career development programs at the applicant institution, but the proposed PSDP research experiences must be distinct from those of career development programs currently receiving Federal support.
For more information on this funding opportunity, click on the following link: http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-12-209.html