The R21 grant is meant to facilitate the award of larger regular research project grant (R01) applications by providing investigators with limited funds and time to pursue initial studies to obtain preliminary data for larger, more fully developed research projects. However, the NHLBI has determined that this grant mechanism is not having the effect or the impact on its research grant portfolio in the manner for which it was originally intended.
Consequently, the NHLBI will no longer accept investigator-initiated R21 applications in response to the NIH's Parent Funding Opportunity Announcement (FOA), NIH Exploratory Developmental Research Grant Program (Parent R21). Investigator-initiated R21 applications will not be accepted for review and funding beyond Fiscal Year 2012. Therefore, the last receipt dates for NHLBI investigator-initiated R21 grant applications are October 16, 2011 for new applications and November 16, 2011 for resubmission (amended) applications. Individuals who submit a new investigator-initiated R21 application for the October 16, 2011 receipt date will not be allowed to revise and resubmit their applications.
In the future, the NHLBI may issue highly targeted Funding Opportunity Announcements for R21 grant applications when scientific opportunities and needs arise that will benefit from the features and requirements of the R21 mechanism.